Update on the Kelch-like (KLHL) gene family | Human ...

2013-5-15 · The Kelch-like (KLHL) gene family encodes a group of proteins that generally possess a BTB/POZ domain, a BACK domain, and five to six Kelch motifs. BTB domains facilitate protein binding and dimerization. The BACK domain has no known function yet is of functional importance since mutations in this domain are associated with disease. Kelch domains form a …bnlearn - References2022-1-1 · I. A. Beinlich, H. J. Suermondt, R. M. Chavez, and G. F. Cooper. The ALARM Monitoring System: A Case Study with Two Probabilistic Inference Techniques for Belief Networks. In Proceedings of the 2nd European Conference on Artificial Intelligence in Medicine, pages 247-256.

Genetically modified foods: safety, risks and public ...

2012-12-19 · Teshima R, Akiyama H, Okunuki H, Sakushima J-i, Goda Y, Onodera H, Sawada J-i, Toyoda M. Effect of GM and non-GM soybeans on the immune system of BN rats and B10A mice. J Food Hyg Soc Jpn. 2000; 41:188–193. doi: 10.3358/shokueishi.41.188. [Google Scholar]Static and dynamic aspects of DNA charge transfer: a .. this work, we approach the impact of dynamic and static disorder on DNA charge transfer from a theoretical and numerical perspective. Disordered or defect geometries are either realized via molecular dynamics simulations using a classical force field or by experimentally determined DNA bulge structures. We apply a chemically specific, atomically resolved extended …

Publications

2014-11-1 ·  1. ( 2021.01~2024.12 ),,5 5 . 2. ( 2019.11~2024.10 ),, 415 . 3. ( 2018.01~2020.12 ),, 180 .Kelch-like homologue 9 mutation is associated with an ...Genome-wide linkage analysis in this family revealed a new locus for distal myopathy at 9p21.2-p22.3 (multipoint logarithm of the odds ratio=4.21). By positional cloning we found a heterozygous mutation L95F in the Kelch-like homologue 9 gene, encoding a bric-a-brac Kelch protein. Molecular modelling indicated that the mutation may interfere ...

,PMF,,WHAM_rogerzhanglijie ...

2012-10-30 · 4。。,。。,""。,,NPT,NVT,,。—AMBERA3:MM-PBSA - ...2018-1-28 · : AMBER ADVANCED TUTORIAL 3: MM-PBSAPerl Version By Ross Walker & Thomas Steinbrecher Python Version By Dwight McGee, Bill Miller III, & Jason Swails 2018-01-28 06:39:37 : ; : mm_pbsaRAS-RAF, .

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Abstract. Satellite-retrieved solar-induced chlorophyll fluorescence (SIF) has shown great potential to monitor the photosynthetic activity of terrestrial ecosystems. However, several issues, including low spatial and temporal resolution of the gridded datasets and high uncertainty of the individual retrievals, limit the applications of SIF.2009,NEST,",",。3000m2,1000m2,、、,ISO 9001、ISO 13485、ISO 11137、FDA、CE ...

Accelerating recurrent Ising machines in photonic ...

In combination, the sampler calculates the input spins for the subsequent algorithm step using the following expression: (2) th S → ( t + 1) = f θ → th ( N ( C S → ( t), ϕ)), where N ( μ, ϕ) is the normal distribution with mean, μ, and standard deviation, ϕ. …Quantifying the effect of forest age in annual net forest ...2018-12-7 · Forests cover about 30% of the Earth''s terrestrial surface and store around 90% of terrestrial vegetation carbon (C) (Canadell et al 2000, Gower 2003, Le Quéré et al 2018), indicating their fundamental role in terrestrial C dynamics (Bonan 2008, Beer et al 2010, Pan et al 2011, Hicke et al 2012, Carvalhais et al 2014).However, the functioning of forest ecosystems …

A New Family of Ultralow Loss Reversible Phase‐Change ...

2020-7-9 · Above 30 nm, a thicker layer would support additional modes, which was prevented here to achieve a meaningful comparison. The transmission of the PCM-cladded waveguides was measured using a 10 mW, narrow linewidth swept source around 1550 nm and was normalized to the grating coupler loss (10 dB ± 0.9 dB), using the average insertion losses of ...Methane emission dynamics from a Danish landfill: The ...This study investigates temporal variability on landfill methane (CH 4) emissions from an old abandoned Danish landfill, caused by the rate of changes in barometric pressure.Two different emission quantification techniques, namely the dynamic tracer dispersion method (TDM) and the eddy covariance method (EC), were applied simultaneously and their results compared.

ESSD

2021-9-7 · 3.2 ERA5. ERA5 is the latest comprehensive ECMWF reanalysis and has replaced ERA-Interim. It is based on a version of the ECMWF IFS (Cy41r2) that was operational in 2016. ERA5 provides hourly estimates of the global atmosphere, land surface, and ocean waves from 1950 and is updated daily with a latency of 5 d.BG - A global spatially contiguous solar-induced ...Abstract. Satellite-retrieved solar-induced chlorophyll fluorescence (SIF) has shown great potential to monitor the photosynthetic activity of terrestrial ecosystems. However, several issues, including low spatial and temporal resolution of the …

Department Biogeochemical Integration | People / …

Scientist, Leader of the Global Diagnostics Ecohydrological and Biogeochemical Modelling group room: C 1.004 (tower) phone: +49 3641 576261 email: Martin.Jung(at)bgc-jena.mpg Decrypting a cryptic allosteric pocket in H. pylori ...2021-12-10 · Helicobacter pylori (H. pylori) is a spiral-shaped Gram-negative pathogenic bacterium estimated to infect more than half of the world''s …

ESSD

2021-12-21 · Abstract. Land evaporation (ET) plays a crucial role in the hydrological and energy cycle. However, the widely used model-based products, even though helpful, are still subject to great uncertainties due to imperfect model parameterizations and forcing data. The lack of available observed data has further complicated estimation partment Biogeochemical Integration | People / …Scientist, Leader of the Global Diagnostics Ecohydrological and Biogeochemical Modelling group room: C 1.004 (tower) phone: +49 3641 576261 email: Martin.Jung(at)bgc-jena.mpg

Static and dynamic aspects of DNA charge transfer: a ...

In this work, we approach the impact of dynamic and static disorder on DNA charge transfer from a theoretical and numerical perspective. Disordered or defect geometries are either realized via molecular dynamics simulations using a classical force field or by experimentally determined DNA bulge structures. We apply a chemically specific, atomically resolved extended …Identify potent SARS-CoV-2 main protease inhibitors via ...2020-11-3 · Drug repurposing effort for treatment of a new disease, such as COVID-19, usually starts from a virtual screening of existing drugs, followed by experimental validation, but the actual hit rate is generally rather low with traditional computational methods. It has been demonstrated that a new virtual screening approach with accelerated free energy perturbation-based …

Stabilizing spin systems via symmetrically tailored RKKY ...

2019-6-12 · e Consecutively recorded spin-resolved line scans along the dashed line in (d) stacked on top of each other (V = 3 mV, I = 20 pA, B = 0 T, T = 300 mK, scanning time per line = 614 ms) Full size ...Single-cell analysis reveals effective siRNA delivery in ...RNA-based therapeutics using RNA interference, including small interfering and short hairpin RNAs (siRNA/shRNA), adenosine deaminase acting on RNA (ADAR), and CRISPR RNAs (1, 2), can be designed to selectively target core tumor signaling pathways ().While minimally invasive systemic delivery of RNA to intracranial malignancies offers several advantages over …

Synergy and Complementarity between Focused Machine ...

2021-12-10 · Using a paired t test, the relatively small difference in prediction errors between QuanSA and FEP + was not statistically significant (p-value = 0.24). However, the hybrid model performed statistically better than FEP + alone (p-value = 0.002) and better than structure-guided QuanSA alone (the paired t test p-value of 0.09 just misses weak ...Genetically modified foods: safety, risks and public ...2012-12-19 · Teshima R, Akiyama H, Okunuki H, Sakushima J-i, Goda Y, Onodera H, Sawada J-i, Toyoda M. Effect of GM and non-GM soybeans on the immune system of BN rats and B10A mice. J Food Hyg Soc Jpn. 2000; 41:188–193. doi: 10.3358/shokueishi.41.188. [Google Scholar]

M1_M2

2013-10-1 · M1_M2. (30973807) 、 Y2008C101)、 ( 2012GSF11908) ( 2011-28) : ( 1978,,,, ...AMBERA3:MM-PBSA|Jerkwin2018-1-28 · AMBERA3:MM-PBSA. Python Version By Dwight McGee, Bill Miller III, & Jason Swails. mm_pbsa RAS-RAF, . mmpbsa_py .

Decrypting a cryptic allosteric pocket in H. pylori ...

2021-12-10 · Helicobacter pylori (H. pylori) is a spiral-shaped Gram-negative pathogenic bacterium estimated to infect more than half of the world''s …Kelch-like homologue 9 mutation is associated with an ...Genome-wide linkage analysis in this family revealed a new locus for distal myopathy at 9p21.2-p22.3 (multipoint logarithm of the odds ratio=4.21). By positional cloning we found a heterozygous mutation L95F in the Kelch-like homologue 9 gene, encoding a bric-a-brac Kelch protein. Molecular modelling indicated that the mutation may interfere ...

Genetically modified foods: safety, risks and public ...

2012-12-19 · Teshima R, Akiyama H, Okunuki H, Sakushima J-i, Goda Y, Onodera H, Sawada J-i, Toyoda M. Effect of GM and non-GM soybeans on the immune system of BN rats and B10A mice. J Food Hyg Soc Jpn. 2000; 41:188–193. doi: 10.3358/shokueishi.41.188. [Google Scholar]Department Biogeochemical Integration | People / …Scientist, Leader of the Global Diagnostics Ecohydrological and Biogeochemical Modelling group room: C 1.004 (tower) phone: +49 3641 576261 email: Martin.Jung(at)bgc-jena.mpg

Accelerating recurrent Ising machines in photonic ...

In combination, the sampler calculates the input spins for the subsequent algorithm step using the following expression: (2) th S → ( t + 1) = f θ → th ( N ( C S → ( t), ϕ)), where N ( μ, ϕ) is the normal distribution with mean, μ, and standard deviation, ϕ. …Provo man stranded in mountain snowstorm hikes over 30 ...2021-12-27 · Provo man stranded in mountain snowstorm hikes over 30 miles for help. A Provo man is recovering and feeling grateful after hiking more than 30 miles after becoming stranded overnight in the ...

Methane emission dynamics from a Danish landfill: The ...

This study investigates temporal variability on landfill methane (CH 4) emissions from an old abandoned Danish landfill, caused by the rate of changes in barometric pressure.Two different emission quantification techniques, namely the dynamic tracer dispersion method (TDM) and the eddy covariance method (EC), were applied simultaneously and their results compared.daoshi.shsmu .cn Zhang Q,Chen H,Wang Y,Zhang C,Tang Z,Li H,Huang X,Ouyang F,Huang H, Liu Z. () Severe vitamin D deficiency in the first trimester is associated with placental inflammation ...

ESSD

2021-9-7 · 3.2 ERA5. ERA5 is the latest comprehensive ECMWF reanalysis and has replaced ERA-Interim. It is based on a version of the ECMWF IFS (Cy41r2) that was operational in 2016. ERA5 provides hourly estimates of the global atmosphere, land surface, and ocean waves from 1950 and is updated daily with a latency of 5 d.ESSD - Mapping global forest age from forest inventories ...2021-10-26 · Abstract. Forest age can determine the capacity of a forest to uptake carbon from the atmosphere. However, a lack of global diagnostics that reflect the forest stage and associated disturbance regimes hampers the quantification of age-related differences in forest carbon dynamics. This study provides a new global distribution of forest age circa 2010, estimated …

Identify potent SARS-CoV-2 main protease inhibitors via ...

2020-11-3 · Drug repurposing effort for treatment of a new disease, such as COVID-19, usually starts from a virtual screening of existing drugs, followed by experimental validation, but the actual hit rate is generally rather low with traditional computational methods. It has been demonstrated that a new virtual screening approach with accelerated free energy perturbation-based …Kelch-like homologue 9 mutation is associated with an ...Genome-wide linkage analysis in this family revealed a new locus for distal myopathy at 9p21.2-p22.3 (multipoint logarithm of the odds ratio=4.21). By positional cloning we found a heterozygous mutation L95F in the Kelch-like homologue 9 gene, encoding a bric-a-brac Kelch protein. Molecular modelling indicated that the mutation may interfere ...

A New Family of Ultralow Loss Reversible Phase‐Change ...

2020-7-9 · Above 30 nm, a thicker layer would support additional modes, which was prevented here to achieve a meaningful comparison. The transmission of the PCM-cladded waveguides was measured using a 10 mW, narrow linewidth swept source around 1550 nm and was normalized to the grating coupler loss (10 dB ± 0.9 dB), using the average insertion losses of ...Accelerating recurrent Ising machines in photonic .. combination, the sampler calculates the input spins for the subsequent algorithm step using the following expression: (2) th S → ( t + 1) = f θ → th ( N ( C S → ( t), ϕ)), where N ( μ, ϕ) is the normal distribution with mean, μ, and standard deviation, ϕ. …

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J Agric Food Chem. 2015;63(27):6221-30. (IF 2.9) 35 Tang X, Shen T, Jiang X, Xia M, Sun X, Guo H*, Ling W*. Purified anthocyanins from bilberry and black currant attenuate hepatic mitochondrial dysfunction and steatohepatitis in mice with methionine and ...Stabilizing spin systems via symmetrically tailored RKKY ...2019-6-12 · e Consecutively recorded spin-resolved line scans along the dashed line in (d) stacked on top of each other (V = 3 mV, I = 20 pA, B = 0 T, T = 300 mK, scanning time per line = 614 ms) Full size ...

Single-cell analysis reveals effective siRNA delivery in ...

RNA-based therapeutics using RNA interference, including small interfering and short hairpin RNAs (siRNA/shRNA), adenosine deaminase acting on RNA (ADAR), and CRISPR RNAs (1, 2), can be designed to selectively target core tumor signaling pathways ().While minimally invasive systemic delivery of RNA to intracranial malignancies offers several advantages over …Influence of infrared (IR) heating parameters upon the ...Untreated grains at the optimum MC of 12.4 per cent exhibited H s, C s and S s as 8.80 N/mm 2, 1.54 N/mm 2 and 1.30 N/mm 2, respectively. The results obtained are in agreement with the observations made by Oomah, Kotzeva, Allen, and Bassinello (2014) that exposure of conditioned grains to IR heating decreases the dehulling force.

Training of photonic neural networks through in situ ...

Recently, integrated optics has gained interest as a hardware platform for implementing machine learning algorithms. Of particular interest are artificial neural networks, since matrix-vector multiplications, which are used heavily in artificial neural networks, can be done efficiently in photonic circuits. The training of an artificial neural network is a crucial step in its application.AMT - ACTRIS non-methane hydrocarbon intercomparison ...The performance of 20 European laboratories involved in long-term non-methane hydrocarbon (NMHC) measurements was assessed with respect to ACTRIS and GAW data quality objectives. The participants were asked to measure both a 30-component NMHC mixture in nitrogen and whole air. The NMHCs were analysed either by GC-FID or GC-MS.

Intrinsically disordered proteins access a range of ...

Polymers and IDPs that exhibit liquid-liquid phase separation belong to one of two classes: They exhibit lower critical solution temperature (LCST) or upper critical solution temperature (UCST) phase behavior (10, 12); and a smaller subset exhibit both behaviors (12, 13) .For polymers that exhibit LCST phase behavior, below a critical temperature—the cloud point temperature (T …Influence of infrared (IR) heating parameters upon the ...Untreated grains at the optimum MC of 12.4 per cent exhibited H s, C s and S s as 8.80 N/mm 2, 1.54 N/mm 2 and 1.30 N/mm 2, respectively. The results obtained are in agreement with the observations made by Oomah, Kotzeva, Allen, and Bassinello (2014) that exposure of conditioned grains to IR heating decreases the dehulling force.